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Two-dimensional polyacrylamide gel electrophoresis database


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Searching in 'USC-OGP 2-DE database' for entry matching: GRP75_HUMAN




USC-OGP 2-DE database:  GRP75_HUMAN


GRP75_HUMAN


General information about the entry
View entry in simple text format
Entry nameGRP75_HUMAN
Primary accession numberP38646
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Stress-70 protein, mitochondrial; AltName: Full=75 kDa glucose-regulated protein; Short=GRP-75; AltName: Full=Heat shock 70 kDa protein 9; AltName: Full=Mortalin; Short=MOT; AltName: Full=Peptide-binding protein 74; Short=PBP74; Flags: Precursor;.
Gene nameName=HSPA9
Synonyms=GRP75, HSPA9B, mt-HSP70
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.34; Mw=72160



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.50; Mw=80748

Cross-references
UniProtKB/Swiss-ProtP38646; GRP75_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameGRP75_HUMAN
Primary accession numberP38646
Secondary accession number(s) B2RCM1 P30036 P31932 Q1HB43 Q53H23 Q6GU03 Q9BWB7 Q9UC56
Sequence was last modified on May 27, 2002 (version 2)
Annotations were last modified on March 15, 2017 (version 187)
Name and origin of the protein
DescriptionRecName: Full=Stress-70 protein, mitochondrial; AltName: Full=75 kDa glucose-regulated protein; Short=GRP-75; AltName: Full=Heat shock 70 kDa protein 9; AltName: Full=Mortalin; Short=MOT; AltName: Full=Peptide-binding protein 74; Short=PBP74; Flags: Precursor;
Gene nameName=HSPA9
Synonyms=GRP75, HSPA9B, mt-HSP70
Encoded onName=HSPA9; Synonyms=GRP75, HSPA9B, mt-HSP70
Keywords3D-structure; Acetylation; ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Disease mutation; Dwarfism; Methylation; Mitochondrion; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL11066; -; NOT_ANNOTATED_CDS; mRNA
EMBLL15189; AAA67526.1; -; mRNA
EMBLAK315177; BAG37618.1; -; mRNA
EMBLAK222758; BAD96478.1; -; mRNA
EMBLDQ531046; ABF50973.1; -; Genomic_DNA
EMBLCH471062; EAW62129.1; -; Genomic_DNA
EMBLBC000478; AAH00478.1; -; mRNA
EMBLBC024034; AAH24034.1; -; mRNA
CCDSCCDS4208.1; -; .
PIRB48127; B48127; .
RefSeqNP_004125.3; NM_004134.6; .
UniGeneHs.184233; -; .
PDB3N8E; X-ray; 2.80 A; A/B=439-597
PDB4KBO; X-ray; 2.80 A; A=52-431
PDBsum3N8E; -; .
PDBsum4KBO; -; .
ProteinModelPortalP38646; -; .
SMRP38646; -; .
BioGrid109545; 213; .
IntActP38646; 58; .
MINTMINT-1143092; -; .
STRING9606.ENSP00000297185; -; .
iPTMnetP38646; -; .
PhosphoSitePlusP38646; -; .
SwissPalmP38646; -; .
BioMutaHSPA9; -; .
DMDM21264428; -; .
DOSAC-COBS-2DPAGEP38646; -; .
OGPP38646; -; .
REPRODUCTION-2DPAGEIPI00007765; -; .
SWISS-2DPAGEP38646; -; .
UCD-2DPAGEP38646; -; .
EPDP38646; -; .
MaxQBP38646; -; .
PaxDbP38646; -; .
PeptideAtlasP38646; -; .
PRIDEP38646; -; .
TopDownProteomicsP38646; -; .
DNASU3313; -; .
EnsemblENST00000297185; ENSP00000297185; ENSG00000113013; .
GeneID3313; -; .
KEGGhsa:3313; -; .
UCSCuc003ldf.4; human; .
CTD3313; -; .
DisGeNET3313; -; .
GeneCardsHSPA9; -; .
HGNCHGNC:5244; HSPA9; .
HPACAB005219; -; .
HPAHPA000898; -; .
MalaCardsHSPA9; -; .
MIM182170; phenotype; .
MIM600548; gene; .
MIM616854; phenotype; .
neXtProtNX_P38646; -; .
OpenTargetsENSG00000113013; -; .
PharmGKBPA162391712; -; .
eggNOGKOG0102; Eukaryota; .
eggNOGCOG0443; LUCA; .
GeneTreeENSGT00860000133890; -; .
HOVERGENHBG051845; -; .
InParanoidP38646; -; .
KOK04043; -; .
OMAEKMAPPQ; -; .
OrthoDBEOG091G0386; -; .
PhylomeDBP38646; -; .
TreeFamTF105046; -; .
ReactomeR-HSA-1268020; Mitochondrial protein import; .
ReactomeR-HSA-3371453; Regulation of HSF1-mediated heat shock response; .
SIGNORP38646; -; .
ChiTaRSHSPA9; human; .
EvolutionaryTraceP38646; -; .
GeneWikiHSPA9; -; .
GenomeRNAi3313; -; .
PROPR:P38646; -; .
ProteomesUP000005640; Chromosome 5; .
BgeeENSG00000113013; -; .
ExpressionAtlasP38646; baseline and differential; .
GenevisibleP38646; HS; .
GOGO:0005737; C:cytoplasm; TAS:ProtInc; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL; .
GOGO:0005739; C:mitochondrion; TAS:UniProtKB; .
GOGO:0043209; C:myelin sheath; IEA:Ensembl; .
GOGO:0005730; C:nucleolus; IEA:UniProtKB-SubCell; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; .
GOGO:0051082; F:unfolded protein binding; TAS:UniProtKB; .
GOGO:0030218; P:erythrocyte differentiation; IMP:UniProtKB; .
GOGO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; .
GOGO:0045647; P:negative regulation of erythrocyte differentiation; IMP:UniProtKB; .
GOGO:1902037; P:negative regulation of hematopoietic stem cell differentiation; IEA:Ensembl; .
GOGO:0006611; P:protein export from nucleus; IEA:Ensembl; .
GOGO:0006457; P:protein folding; IEA:InterPro; .
Gene3D1.20.1270.10; -; 1; .
Gene3D2.60.34.10; -; 1; .
HAMAPMF_00332; DnaK; 1; .
InterProIPR012725; Chaperone_DnaK; .
InterProIPR018181; Heat_shock_70_CS; .
InterProIPR029048; HSP70_C; .
InterProIPR029047; HSP70_peptide-bd; .
InterProIPR013126; Hsp_70_fam; .
PfamPF00012; HSP70; 1; .
PRINTSPR00301; HEATSHOCK70; .
SUPFAMSSF100920; SSF100920; 1; .
TIGRFAMsTIGR02350; prok_dnaK; 1; .
PROSITEPS00297; HSP70_1; 1; .
PROSITEPS00329; HSP70_2; 1; .
PROSITEPS01036; HSP70_3; 1; .



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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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